Key Publications: Tara Spires-Jones

Tara Spires-Jones

Key Publications

1Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, Bacskai BJ, Hyman BT. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci. 2005 Aug 3;25(31):7278-87. PubMed PMID: 16079410; PubMed Central PMCID: PMC1820616.

2: Santacruz K, Lewis J, Spires TL, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, Kuskowski M, Hyman B, Hutton M, Ashe KH. Tau suppression in a neurodegenerative mouse model improves memory function. Science. 2005 Jul 15;309(5733):476-81. PubMed PMID: 16020737; PubMed Central PMCID: PMC1574647.

3: Meyer-Luehmann M, Spires-Jones TL, Prada C, GarciaAlloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer’s disease. Nature. 2008 Feb 7;451(7179):720-4. doi: 10.1038/nature06616. PubMed PMID: 18256671; PubMed Central PMCID: PMC3264491.

4: Koffie R, Meyer-Luehmann M, Mielke M, Garcia-Alloza M, Micheva KD, Smith SJ, Lee V, Hyman BT, Spires-Jones TL. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):4012-7. doi: 10.1073/pnas.0811698106. Epub 2009 Feb 19. PubMed PMID: 19228947; PubMed Central PMCID: PMC2656196.

5: Koffie RM, Hashimoto T, Tai H-C, Kay KR, Serrano-Pozo A, Joyner D, Hou S, Kopeikina KJ, Frosch MP, Lee VM, Holtzman DM, Hyman BT, Spires-Jones TL. Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β. Brain. 2012 Jul;135(Pt 7):2155-68. doi: 10.1093/brain/aws127. Epub 2012 May 26. PubMed PMID: 22637583; PubMed Central PMCID: PMC3381721.

6: de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai B, Spires-Jones TL, Hyman BT. Caspase activation precedes and leads to tangles. Nature. 2010 Apr 22;464(7292):1201-4. doi: 10.1038/nature08890. Epub 2010 Mar 31. PubMed PMID: 20357768; PubMed Central PMCID: PMC3091360.

7: Kopeikina KJ, Carlson GA, Pitstick R, Ludvigson AE, Peters A, Leubke JI, Koffie RM, Frosch MP, Hyman BT, Spires-Jones TL. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer’s disease brain. Am J Pathol. 2011 Oct;179(4):2071-82. doi: 10.1016/j.ajpath.2011.07.004. Epub 2011 Aug 18. PubMed PMID: 21854751; PubMed Central PMCID: PMC3181340.

8: de Calignon A, Polydoro M, Suárez-Calvert M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N,Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. Propagation of tau pathology in a model of early Alzheimer’s disease. Neuron. 2012 Feb 23;73(4):685-97. doi: 10.1016/j.neuron.2011.11.033. Erratum in: Neuron. 2012 Oct 18;76(2):461. PubMed PMID: 22365544; PubMed Central PMCID: PMC3292759.

9: Kopeikina KJ, Polydoro M, Tai H, Yaeger E, Carlson GA, Pitstick R, Hyman BT, Spires-Jones TL. Synaptic alterations in the rTg4510 mouse model of tauopathy. J Comp Neurol. 2013 Apr 15;521(6):1334-53. doi: 10.1002/cne.23234. PubMed PMID: 23047530; PubMed Central PMCID: PMC3725804.

10: Kay KR, Smith C, Wright AK, Serrano-Pozo A, Pooler AM, Koffie R, Bastin ME, Bak TH, Abrahams S, Kopeikina KJ, McGuone D, Frosch MP, Gillingwater TH, Hyman BT, SpiresJones TL.  Studying synapses in human brain with array tomography and electron microscopy. Nat Protoc. 2013;8(7):1366-80. doi: 10.1038/nprot.2013.078. Epub 2013 Jun 20. PubMed PMID: 23787894; PubMed Central PMCID: PMC3712649.