Mutation in PARK15 are associated with a juvenile form of parkinsonism. PARK15 encodes FBXO7, a subunit of the SCF E3 ubiquitin ligase. Specific deletion of FBXO7 in glutamatergic or dopaminergic neurons results in motor deficits, supporting a fundamental role for FBXO7 in neurons. While the loss of FBXO7 has little or no effect on cell survival, it affects brain wiring and connectivity.
In line with the phenotype of PARK15 KO mice, Parkinson disease (PD) is viewed as a synaptopathy. In addition to motor defects, PD is associated with olfactory dysfunction, its symptoms preceding motor deficits.
A postdoctoral position for neuro- and optophysiology is available at the Department of Developmental Neurophysiology, University Medical Center Hamburg, Germany.
Our group investigates the synchronized patterns of electrical activity in the immature brain, their relevance for the development of cognitive and behavioral abilities and their impairment associated with neurological and neuropsychiatric disorders.
For more details: www.opatzlab.com
Project title: Understanding the contribution of the motor system to action preparation
Principal investigator and host laboratory: Julie Duque, Institute of Neuroscience, UCLouvain, Brussels, Belgium
A Postdoctoral Research Fellow position (24 months) is available in the laboratory of Julie Duque located in Brussels, www.coactionslab.com, at the Institute of Neuroscience of the Université catholique de Louvain.
The lab explores a range of questions pertaining to the cognitive neuroscience of human behavior.