FKNE > Scientific actions > Research

Research

Research

2018, February/April
2018, January
2017, November/December
2017, September/October
2017, June/July/August
2017, May
2017, March/April
2017, January/February
Rapid Neuromodulation of Layer 1 Interneurons in Human Neocortex.

Poorthuis, R.B., Muhammad, K., Wang, M., Verhoog, M.B., Junek, S., Wrana, A., Mansvelder, H.D. and Letzkus, J. J. (2018). Cell Reports 23:951-58.


High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics.

Mager, T., Lopez de la Morena, D., Senn, V., Schlotte, J., D´Errico, A., Feldbauer, K., Wrobel, C., Jung, S., Bodensiek, K., Rankovic, V., Browne, L., Huet, A., Jüttner, J., Wood, P.G., Letzkus, J.J., Moser, T. and Bamberg, E. (2018). Nature Communications 9:1750


Locomotor activity modulates associative learning in mouse cerebellum.

Albergaria C, Silva NT, Pritchett D, Carey MR. (2018). Nature Neuroscience 21:725-735.


In vivo methods for acute modulation of gene expression in the central nervous system.

Cwetsch AW, Pinto B, Savardi A, Cancedda L. Prog Neurobiol. 2018 Apr 22. pii: S0301-0082(17)30146-6. doi: 10.1016/j.pneurobio.2018.04.008. [Epub ahead of print] Review.


Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron.

Elisa Galliano,Eleonora Franzoni, Marine Breton, Annisa N Chand, Darren J Byrne, Venkatesh N Murthy, Matthew S Grubb. Elife. 2018 Apr 20;7. pii: e32373. doi: 10.7554/eLife.32373.


A Go-type opsin mediates the shadow reflex in the annelid Platynereis dumerilii.

Ayers T, Tsukamoto H, Gühmann M, Veedin Rajan VB, Tessmar-Raible K. BMC Biol. 2018 Apr 18;16(1):41. doi: 10.1186/s12915-018-0505-8.


PM20D1 is a quantitative trait locus associated with Alzheimer’s disease.

Sanchez-Mut JV, Heyn H, Silva BA, Dixsaut L, Garcia-Esparcia P, Vidal E, Sayols S, Glauser L, Monteagudo-Sánchez A, Perez-Tur J, Ferrer I, Monk D, Schneider B, Esteller M, Gräff J. Nature Medicine, 2018 May 7. doi: 10.1038/s41591-018-0013-y. [Epub ahead of print].


An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System.

Di Donato V, De Santis F, Albadri S, Auer TO, Duroure K, Charpentier M, Concordet JP, Gebhardt C, Del Bene F. Neuron. 2018 Mar 7;97(5):1049-1062.e6. doi: 10.1016/j.neuron.2018.01.030. 


Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse.

Ahlbeck J, Song L, Chini M, Bitzenhofer SH, Hanganu-Opatz Elife. 2018 Apr 10;7. pii: e33158. doi: 10.7554/eLife.33158.


Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling.

Richter M, Murtaza N, Scharrenberg R, White SH, Johanns O, Walker S, Yuen RKC, Schwanke B, Bedürftig B, Henis M, Scharf S, Kraus V, Dörk R, Hellmann J, Lindenmaier Z, Ellegood J, Hartung H, Kwan V, Sedlacik J, Fiehler J, Schweizer M, Lerch JP, Hanganu-OpatzIL, Morellini F, Scherer SW, Singh KK, Calderon de Anda F. Mol Psychiatry. 2018 Feb 21. doi: 10.1038/s41380-018-0025-5. [Epub ahead of print].


Open source tools for temporally controlled rodent behavior suitable for electrophysiology and optogenetic manipulations.

Solari N*, Sviatkó K*, Laszlovszky T*, Hegedüs P*, Hangya B (2018) Frontiers in Systems Neuroscience, in press.

 

 

ATP-mediated Events in Peritubular Cells Contribute to Sterile Testicular Inflammation

fdaag

Walenta L, Fleck D, Fröhlich /, von Eysmondt H, Arnold G, Spehr J, Schwarzer JU, Köhn F-M, Spehr M, Mayerhofer A (January 2018). Scientific Reports 8: 1431.


DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.

Marneuroinfltiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M.  J Neuroinflammation. 2017 Nov.7.


Dendritic spine actin cytoskeleton in autism spectrum disorder.

fartaerterJoensuu M, Lanoue V, and Hotulainen P. (2017). Prog Neuropsychopharmacol Biol Psychiatry. Sep 1. pii: S0278-5846(17)30414-1. doi: 10.1016/j.pnpbp.2017.08.023. [Epub ahead of print].


Hotspots of Dendritic Spine Turnover Facilitate Learning-related Clustered Spine Addition and Network Sparsity.

fgrteAdam C. Frank, Shan Huang, Miou Zhou, Amos Gdalyahu, George Kastellakis, Ximiao Wen, Tawnie K. Silva, Panayiota Poirazi*, Joshua T. Trachtenberg, and Alcino J. Silva. (*corresponding author). Nature Communications, January 2018.


Impact of thalamocortical input on barrel cortex development*. 

ggtMartini FJ, Moreno-Juan V, Filipchuk A, Valdeolmillos M, López-Bendito G. Neuroscience 2017. *Updated summary on the role of thalamic input integration and identity, neurotransmission and spontaneous activity in cortical map formation and early cross-modal plasticity.


The role of spontaneous neurotransmission in synapse and circuit development. 
ii55i5i7Andreae LC, Burrone J. J Neurosci Res. 2018 Mar;96(3):354-359. doi: 10.1002/jnr.24154. Epub 2017 Oct 16.


Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis. 

gtytyHenstridge CM, Sideris DI, Carroll E, Rotariu S, Salomonsson S, Tzioras M, McKenzie CA, Smith C, von Arnim CAF, Ludolph AC, Lulé D, Leighton D, Warner J, Cleary E, Newton J, Swingler R, Chandran S, Gillingwater TH, Abrahams S, Spires-Jones TL. Acta Neuropathol. 2017 Dec 22. doi: 10.1007/s00401-017-1797-4. [Epub ahead of print]. PMID: 29273900.


Local signals in mouse horizontal cell dendrites. 

Current BiologyChapot CA, Behrens C, Rogerson LE, Baden T, Pop S, Berens P, Euler T§, Schubert T§Current Biology 27(1-13). direct link.  (bioRxiv version).


Zebrafish differentially process colour across visual space to match natural scenes. 

BioRvixZimmermann MJY*, Nevala NE*, Yoshimatsu T*, Osorio D, Nilsson DE, Berens P, Baden T§ bioRxiv doi: https://doi.org/10.1101/230144.


Behavior-dependent activity and synaptic organization of septo-hippocampal GABAergic neurons selectively targeting the hippocampal CA3 area. 

nsndsjJoshi A, Salib M, Viney TJ, Dupret D, Somogyi P. Neuron. December 2017.

 

Review on the use of human stem cells in neurodegeneration research

gt3tgZhou L, Verstreken P. 2018. Current Opinion in Neurobiology.

 


Preview in Neuron describing how alpha-synuclein and tau affect mitochondria(January 2018).

nsndsj

 

 

 

Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development. 

gghgMol Psychiatry 2017. Kathuria A, Nowosiad P, Jagasia R, Aigner S, Taylor RD, Andreae LC, Gatford NJF, Lucchesi W, Srivastava DP, Price J. (Sept. 2017)


Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior.

ewrewe1: Lecca S, Meye FJ, Trusel M, Tchenio A, Harris J, Schwarz MK, Burdakov D, Georges F, Mameli M. Elife. 2017 Sep 5;6. pii: e30697. doi: 10.7554/eLife.30697.


Limiting habenular hyperactivity  ameliorates maternal separation-driven depressive-like symptoms.

fgrte

Tchenio A, Lecca S, Valentinova K, Mameli M.  Nat Commun. 2017 Oct 26;8(1):1135. doi: 10.1038/s41467-017-01192-1.


Assessing amyloid-beta, tau, and glial features in Lothian Birth Cohort 1936 participants post-mortem. 

sdsdScience Matters (in press). Tzioras M, Easter J, Harris S, McKenzie C-A, Smith C, Deary I, Henstridge C, Spires-Jones TL.


The anterior insula bidirectionally modulates cost-benefit decision making on a rodent gambling task.

FaffrDaniel ML, Cocker PJ, Lacoste J, Mar AC, Houeto JL, Belin-Rauscent A & Belin D (2017). Eur J Neurosci. 2017 Nov;46(10):2620-2628. doi: 10.1111/ejn.13689. Epub 2017 Oct 6.


Addictive behaviour in experimental animals: prospects for translation

Everitt, B. J., Giuliano, C., & Belin, D. Philosophical Transactions of the Royal Society B: Biological Sciences https://doi.org/10.1098/rstb.2017-0027


Light on a sensory interface linking the cerebrospinal fluid to motor circuits in vertebrates. 

jddfg

Djenoune L, Wyart C. . J Neurogenet. 2017 Aug 8:1-15. doi: 10.1080/01677063.2017.1359833.


Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae.

KJTDKnafo S, Prendergast A, Thouvenin O, Figueiredo SN,Wyart C. Bio Protoc. 2017 Sep 20;7(18):e2550.doi: 10.21769

 

Two sources of dopamine for the hippocampus

hrttrMcNamara and Dupret. Trends in Neurosci. 2017. July. doi: 10.1016/j.tins.2017.05.005 PMCID: PMC5489110 


Information processing in the vertebrate habenula (August 2017).

Information processing in the vertebrate habenula. Fore S, Palumbo F, Pelgrims R, Yaksi E.Semin Cell Dev Biol. 2017 Aug 7. pii: S1084-9521(16)30437-2. doi: 10.1016/j.semcdb.2017.08.019. [Epub ahead of print] Review. PMID:28797836Fore S, Palumbo F, Pelgrims R, Yaksi E.Semin Cell Dev Biol. 2017 Aug 7. pii: S1084-9521(16)30437-2. doi: 10.1016/j.semcdb.2017.08.019. [Epub ahead of print] Review. PMID:28797836


Virtual Reality for Freely Moving Animals (August 2017).

Nature MethodsStowers JR*, Hofbauer M*, Bastien R, Griessner J, Higgins P, Farooqui S, Fischer RM, Nowikovsky K, Haubensak W, Couzin ID, Tessmar-Raible K@ & Straw AD@ Nature Methods 2017 AOP: August 21 DOI: 10.1038/nmeth.4399


High-dimensional, single-cell characterization of the brain’s immune compartment (July 2017).

Nature NeuroscienceKorin B, Ben-Shaanan TL, Schiller M, Dubovik T, Azulay-Debby H, Boshnak NT, Koren T, Rolls A. Nat Neurosci. 2017 Jul 24


Dual-transmitter systems regulating arousal, attention, learning and memory (July 2017).

Ma S, Hangya B, Leonard C, Wisden W, Gundlach AL. Neurosci Biobehav Rev, in press(2017).


Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion (June 2017).

eLIFESteven Knafo, Kevin Fidelin, Andrew Prendergast, Po-En Brian Tseng, Alexandre Parrin, Charles William Dickey, Urs Lucas Böhm, Sophie Nunes FIgueiredo, Olivier Thouvenin, Hugues Pascal-Moussellard, Claire Wyart. eLIFE, June 2017. 


Thalamic neuronal specification and early circuit formation (July 2017).

Developmental NeurobiologyGezelius H, López-Bendito G. . Dev Neurobiol. 2017 Jul;77(7):830-843. doi: 10.1002/dneu.22460. Epub 2016 Nov 4. Review. PubMed PMID: 27739248.


Increased microglial phagocytosis regulates enhanced amyloid clearance and excessive synaptic pruning through TDP-43. 

nsndsjRosa C. Paolicelli, Ali Jawaid, Andrea Valeri, Christopher M. Henstridge, Mario Merlini, John L. Robinson, Edward B. Lee, Stanley Appel, Tara Spires-Jones, Virginia Man-Yee Lee, John Q. Trojanowski, Paul E. Schulz and Lawrence Rajendran. Neuron (in press).


Acute stress attenuates appetitive behaviors for social and sexual stimuli in long-term morphine-withdrawn rats.

geyywBai Y, Belin D, Zheng X, Zhang Y & Liu Z(2017).  Psychopharmacology. doi:10.1007/s00213-017-4571-3

 

 

Tau association with synaptic vesicles causes presynaptic dysfunction (May 2017).

Nature CommunicationsZhou L, McInnes J, Wierda K, Holt M, Herrmann AG, Jackson RJ, Wang YC, Swerts J, Beyens J, Miskiewicz K, Vilain S, Dewachter I, Moechars D, De Strooper B, Spires-Jones TL, De Wit J, Verstreken P. (2017). Nat Commun. 8:15295. doi: 10.1038/ncomms15295.


Two sources of dopamine for the hippocampus (May 2017). 

TrendsMcNamara and Dupret. Trends in Neurosci. 2017, Science Direct.

 


New waves in dendritic spine actin cytoskeleton: From branches and bundles to rings, from actin binding proteins to post-translational modifications (May 2017).

MCNBertling E, Hotulainen P. , Mol Cell Neurosci. 2017 May 4. pii: S1044-7431(16)30280-9. doi: 10.1016/j.mcn.2017.05.002. [Epub ahead of print] Review.


An Overview of Monthly Rhythms and Clocks. 

Frontiers in NeurologyRaible F, Takekata H, Tessmar-Raible K.Front Neurol. 2017 May 12;8:189. doi: 10.3389/fneur.2017.00189. eCollection 2017.

 


Autophagy in the presynaptic compartment in health and disease (May 2017).

Cell BiologyVijayan V, Verstreken P. (2017). J Cell Biol. 216(7):1895-1906. doi: 10.1083/jcb.201611113. 10.1038/ncomms15295.


Openspritzer: an open hardware pressure ejection system for reliably delivering picolitre volumes (May 2017).

BioRvixForman CJ§, Tomes H, Mbobo B, Burman, RJ, Jacobs M, Baden T§, Raimondo JV§. Nat Sci Rep. 7:2188. (bioRxiv version). pdf.


General features of inhibition in the inner retina (May 2017).

Journal of PhysiologyFranke K and Baden T.J Physiol; (2017). advance online pdf.

 


Individual vulnerability for compulsive alcohol seeking in rats: Evidence for a long-lasting compulsive alcohol seeking phenotype in rats. 

wwGiuliano C, Peña-Oliver Y, Goodlett CR, Cardinal RN, Robbins TW, Bullmore ET, Belin D* & Everitt BJ* (2017). Neuropsychopharmacology. 2017 May 29. doi: 10.1038/npp.2017.105.

Monitoring the Right Collection: The Central Cholinergic Neurons as an Instructive Example (April 2017).

hhhSviatkó K, Hangya B. Frontiers in Neural Circuits, 11:31.

 


Impact of thalamocortical input on barrel cortex development. 

ggtNeuroscience. 2017  Apr 13. Martini FJ, Moreno-Juan V, Filipchuk A, Valdeolmillos M, López-Bendito G. pii: S0306-4522(17)30244-0. doi: 10.1016/j.neuroscience.2017.04.005. [Epub ahead of print] PubMed PMID: 28412498.


Membrane permeation of arginine-rich cell-penetrating peptides independent of transmembrane potential as a function of lipid composition and membrane fluidity (April 2017).

ueuuuWallbrecher R⁠, Ackels T, Olea⁠ RA, Klein MJ, Caillon⁠ L, Schiller⁠ J, Bove-Geurts PH, van Kuppevelt⁠ TH, Ulrich⁠ AS, Spehr⁠ M, Adjobo-Hermans⁠ MJW, Brock R (2017). Journal of ControlledRelease 256: 68–78.


Bidirectional regulation over the development and expression of loss of control over cocaine intake by the anterior insula.

geyywRotgé JY, Cocker P, Daniel ML, Belin-Rauscent A, Everitt BJ, Belin D (2017).  Psychopharmacology, doi: 10.1007/s00213-017-4593-x


The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes (April 2017).

fdaagDjenoune L, Desban L, Gomez J, Sternberg JR, Prendergast A, Langui D, Quan FB, Marnas H, Auer TO, Rio JP, Del Bene F, Bardet PL, Wyart C [2017]. Scientific Reports 7:719.


Rate and Temporal Coding Convey Multisensory Information in Primary Sensory Cortices (March 2017).

hrhehtBieler M, Sieben K, Cichon N, Schildt S, Röder B, Hanganu-Opatz IL. (2017b) eNeuro. 20;4(2). doi: 10.1523/ENEURO.0037-17.


Reduced Lateral Inhibition Impairs Olfactory Computations and Behaviors in a Drosophila Model of Fragile X Syndrome (March 2017).

Current BiologyFranco LM, Okray Z, Linneweber GA, Hassan BA, Yaksi E. . Curr Biol. 2017 Apr 24;27(8):1111-1123. doi:10.1016/j.cub.2017.02.065.


The 100 Euro Lab: A 3-D Printable Open Source Platform For Fluorescence Microscopy, Optogenetics And Accurate Temperature Control During Behaviour Of Zebrafish, Drosophila And C. elegans (March 2017).

BioRvixChagas, A.M.$, Prieto Godino, L.L., Arrenberg, A. B. and Baden, T.$. bioRviv doi:https://doi.org/10.1101/122812. direct link.

 

A toolbox for optophysiological experiments in freely moving rats.

Frontiers in NeuroscienceHardung S, Alyahyay M, Eriksson D, Diester I (2017b). Frontiers in Systems Neuroscience 11:27 doi: 10.3389/fnsys.2017.00027. 


A Functional Gradient in the Rodent Prefrontal Cortex Supports Behavioural Inhibition.

Current Biology

Hardung S, Epple R, Jäckel Z, Eriksson D, Uran C, Senn V, Gibor L, Yizhar O, Diester I (2017a). Curr Biol 20:549-555.


Instrument design and protocol for the study of light controlled processes in aquatic organisms, and its application to examine the effect of infrared light on zebrafish (February 2017).

Plos OneDekens MP, Foulkes NS, Tessmar-Raible K. PLoS One. 2017 Feb 17;12(2):e0172038. doi: 10.1371/journal.pone.0172038. eCollection 2017.


Prenatal thalamic waves  regulate cortical area size prior to sensory processing (February 2017).

Moreno-Juan V, Filipchuk A, Antón-Bolaños N, Mezzera C, Gezelius H, Andrés B,  Rodríguez-Malmierca L, Susín R, Schaad O, Iwasato T, Schüle R, Rutlin M, Nelson S, Ducret S, Valdeolmillos M, Rijli FM, López-Bendito G. Nat Commun. 2017Feb 3;8:14172. doi: 10.1038/ncomms14172. PubMed PMID: 28155854; PubMed Central PMCID: PMC5296753.


Motile-Cilia-Mediated Flow Improves Sensitivity and Temporal Resolution of Olfactory Computations (January 2017).

Current BiologyReiten I, Uslu FE, Fore S, Pelgrims R, Ringers C, Diaz Verdugo C, Hoffman M, Lal P, Kawakami K, Pekkan K, Yaksi E, Jurisch-Yaksi N. . Curr Biol. 2017 Jan 23;27(2):166-174. doi: 10.1016/j.cub.2016.11.036.


Layer-specific optogenetic activation of pyramidal neurons causes beta-gamma entrainment of neonatal networks (February 2017).

Nature CommunicationsBitzenhofer SH, Ahlbeck J, Wolff A, Wiegert JS, Gee CE, Oertner TG, Hanganu-Opatz IL. (2017a) Nat Commun. 8:14563. doi: 10.1038/ncomms14563.


A Retinal Ganglion Cell to Report Image Focus? (February 2017).

Current BiologyBaden T, Schaeffel F and Berens P. Visual Neuroscience:  Current Biology http://dx.doi.org/10.1016/j.cub.2016.12.022. direct link. Pdf

 


Inhibition decorrelates visual feature representations in the inner retina (February 2017).

Nature1Franke K*, Berens P*, Schubert T, Bethge M, Euler T§, Baden T§.Nature; doi: 10.1038/nature21394. direct link, pdf. (bioRxiv version). News and Views by Dick Masland.

 

X